The manufacturers of the erythropoietic agents Procrit, Aranesp and Epogen have provided updated information about certain antibody-mediated reactions in patients treated with these drugs. Patients taking these drugs can produce antibodies to erythropoietin, resulting in loss of drug activity and pure red cell aplasia or severe anemia. This is most common in patients with chronic renal failure who receive these drugs subcutaneously. The labeling now says that any patient who suddenly stops responding to Procrit, Aranesp or Epogen and who develops severe anemia and a low reticulocyte count should be evaluated. If you suspect an antibody-mediated anemia, stop using the product and contact the manufacturer to perform antibody assays on the patient's blood. If it's found that the patient has developed antibody-mediated anemia, erythropoietic treatment should be permanently discontinued. These patients should not be switched to other erythropoietic proteins because their antibodies could cross-react with these products as well.

hey guys this is just to show you how fucked up long a word can be in english, this is a thing called titin, its pretty much our "muscles" and its actually to long to put into this description, so just gonna put in some facts on it: btw, im not sure you can hear my voice: Titin is the largest known protein, consisting of 26,926 amino acids. The molecular weight of the mature protein is approximately 2,993,442.763 u[3], and it has a theoretical pI of 6.01[4] The protein's empirical chemical formula is C132983H211861N36149O40883S693. It has a theoretical instability index (II) of 39.69, indicating that it would be stable in a test tube. The protein's in vivo half-life, the time it takes for half of the amount of protein in a cell to disappear after its synthesis in the cell, is predicted to be approximately 30 hours (in mammalian reticulocytes).[5]