Demonstrate the cut and paste technique for using fibrin glue in pterygium excision and autografting

Fibrin, one of the primary clotting agents, should "turn on" in the case of an injury to help clot your blood. Then turn off when the bleeding has stopped. In the elderly and those with chronic health conditions, however, these white stringy fibers develop during the healing process, often forming scar tissue. This excess fibrin—from scars, surgeries, or arterial sclerotic plaque (scar tissues of the arteries)—can cause the blood to thicken. The thickened blood acts like a "sludge," preventing oxygen and nutrients from reaching the cells and creating a breeding ground for infectious agents. Thick blood can also be caused by chronic infection, inflammation, and heavy metal toxicity. So keeping your blood—your body's "river of life"—clean and flowing smoothly without infection is vital to staying healthy and feeling better. Research over the past 25 years has shown that Nattokinase—a traditional Japanese folk medicine from Natto—helps strengthen the heart and thin thickened blood by dissolving excess fibrin in the circulatory system. Kinase Plus, a proprietary enzyme blend based on the powerful fibrin-reducing properties of Natto, contains 2,000 fibrinolytic units (FU) in each capsule. More potent than other nattokinase supplements, Kinase Plus helps dissolve fibrin build-up to keep your blood flowing freely and smoothly. And because Kinase Plus is so effective, you only need to take up to three capsules a day to feel better—not the six or 12 suggested for other nattokinase supplements.

Pterygium resection with amnion graft and fibrin glue

19 years old young man with inguinoscrotal right hernia.Decision-making for repair with minimal prosthetic residual material, and no stitches use for best comfort

using gmod9 in HL2

dressage PSG horse

fibrin, reaches its destination and clots the blood

Fibrin has some fun

dressage PSG horse

Dr. Nicholas Nikolov gives William Stuart a facelift using fibrin glue to reduce healing time. The fibrin glue actually "glues" his face back together. First aired on Cosmetic Surgery Live - Chanel 5 London.

THE BLOOD CLOTTING CASCADE 1. A cut occurs and Hageman Factor sticks to the surface of cells near the wound. Bound Hageman Factor reacts with another enzyme called HMK to produce Activate Hageman. 2. Pre Kallikrein reacts with Activated Hageman to produce Kallikrein. 3. Hageman Factor also reacts with HMK and Kallikrein to form Activated Hageman. 4. PTA reacts with Activated Hageman and HMK to produce Activated PTA. 5. Christmas Factor reacts with Activated PTA and Convertin to produce Activated Christmas Factor. 6. Antihemophilic Factor is activated by Thrombin to produce Activated Antihemophilic Factor. 7. Stuart Factor reacts with Activated Christmas Factor and Activated Antihemophilic Factor to produce Activated Stuart Factor. 8. Proconvertin is activated by Activated Hageman Factor to produce Convertin. 9. When a cut occurs, Tissue Factor (which is only found outside of cells) is brought in near the wound where it reacts with Convertin and Stuart Factor to produce Activated Stuart Factor. (Note that step 9 involves an extrinsic process whereas step 7 is an intrinsic process.) 10. Proaccelerin is activated by Thrombin to produce Accelerin. 11a. GLU-Prothrombin reacts with Prothrombin Enzyme and Vitamin K to produce GLA-Prothrombin. (Note that Prothrombin cannot be activated in the GLU form so it must be formed into the GLA form. In this process ten amino acids must be changed from glutamate to gama carboxy glutamate.) 11b. GLA-Prothrombin is them able to bind to Calcium. This allows GLA-Prothrombin to stick to surfaces of cells. Only intact modified Calcium-Prothrombin Complex can bind to the cell membrane and be cleaved by Activated Stuart and Accelerin to produce Thrombin. 12. Prothrombin-Ca (bound to cell surface) is activated by Activated Stuart to produce Thrombin. 13. Prothrombin also reacts with Activated Stuart and Accelerin to produce Thrombin. (Step 13 is much faster than step 12.) 14. Fibrinogen is activated by Thrombin to produce Fibrin. Threads of Fibrin are the final clot. However, it would be more effective if the Fibrin threads could form more cross links with each other. 15. FSF (Fibrin Stabilizing Factor) is activated by Thrombin to form Activated FSF. 16. When Fibrin reacts with Activated FSF many more cross ties are made with other Fibrin filaments to form a more effective clot. Well now, I am wondering to myself whether you are experiencing frustration or intrigue, weariness or excitement. There are a lot of details but let me ask you a leading question. Is this intricate system something that man developed or is it something that man has discovered? Blood clotting is not an invention of man. It is the invention of either God or "Mother Nature" (i.e., it invented itself). Regardless of how you believe the clotting cascade came to be, (Accident or Design) the fact remains that blood clotting is a clear example of irreducible complexity which clearly indicates design. Let us next consider that this irreducibly complex system of blood clotting must have a way to remove the clot once the wound has healed. How is this done? 17a. A blood protein, Plasminogen is activated by + - Pa to produce Plasmin. This acts like tiny chemical scissors which cuts up the Fibrin filaments of the clot. 17b. The rate at which the clot is broken up is controlled by yet another blood protein named Alpha 2 Antiplasm, which in turn inactivates Plasmin. One of the most important parts of this whole blood cloning machine is the ability it has to keep the clotting localized to the area of the wound and to stop the clotting cascade. What is the biggest killer of human beings? That's right, blood clots. Most heart attacks and strokes are caused by blood clots lodging. I believe the way your body shuts down the clotting cascade is as fascinating as the clotting process itself. 18. An%###!hrombin inactivates Activated Christmas, Activated Stuart and Thrombin. 19. Protein C is activated by Thrombin to produce Activated Protein C. 20. Activated Protein C inactivates Accelerin and Activated Antihemophilic. 21. Finally, Thrombomodulin which lines the inside of your blood vessels prevents Thrombin from activating Fibrinogen.

THE BLOOD CLOTTING CASCADE 1. A cut occurs and Hageman Factor sticks to the surface of cells near the wound. Bound Hageman Factor reacts with another enzyme called HMK to produce Activate Hageman. 2. Pre Kallikrein reacts with Activated Hageman to produce Kallikrein. 3. Hageman Factor also reacts with HMK and Kallikrein to form Activated Hageman. 4. PTA reacts with Activated Hageman and HMK to produce Activated PTA. 5. Christmas Factor reacts with Activated PTA and Convertin to produce Activated Christmas Factor. 6. Antihemophilic Factor is activated by Thrombin to produce Activated Antihemophilic Factor. 7. Stuart Factor reacts with Activated Christmas Factor and Activated Antihemophilic Factor to produce Activated Stuart Factor. 8. Proconvertin is activated by Activated Hageman Factor to produce Convertin. 9. When a cut occurs, Tissue Factor (which is only found outside of cells) is brought in near the wound where it reacts with Convertin and Stuart Factor to produce Activated Stuart Factor. (Note that step 9 involves an extrinsic process whereas step 7 is an intrinsic process.) 10. Proaccelerin is activated by Thrombin to produce Accelerin. 11a. GLU-Prothrombin reacts with Prothrombin Enzyme and Vitamin K to produce GLA-Prothrombin. (Note that Prothrombin cannot be activated in the GLU form so it must be formed into the GLA form. In this process ten amino acids must be changed from glutamate to gama carboxy glutamate.) 11b. GLA-Prothrombin is them able to bind to Calcium. This allows GLA-Prothrombin to stick to surfaces of cells. Only intact modified Calcium-Prothrombin Complex can bind to the cell membrane and be cleaved by Activated Stuart and Accelerin to produce Thrombin. 12. Prothrombin-Ca (bound to cell surface) is activated by Activated Stuart to produce Thrombin. 13. Prothrombin also reacts with Activated Stuart and Accelerin to produce Thrombin. (Step 13 is much faster than step 12.) 14. Fibrinogen is activated by Thrombin to produce Fibrin. Threads of Fibrin are the final clot. However, it would be more effective if the Fibrin threads could form more cross links with each other. 15. FSF (Fibrin Stabilizing Factor) is activated by Thrombin to form Activated FSF. 16. When Fibrin reacts with Activated FSF many more cross ties are made with other Fibrin filaments to form a more effective clot. Well now, I am wondering to myself whether you are experiencing frustration or intrigue, weariness or excitement. There are a lot of details but let me ask you a leading question. Is this intricate system something that man developed or is it something that man has discovered? Blood clotting is not an invention of man. It is the invention of either God or "Mother Nature" (i.e., it invented itself). Regardless of how you believe the clotting cascade came to be, (Accident or Design) the fact remains that blood clotting is a clear example of irreducible complexity which clearly indicates design. Let us next consider that this irreducibly complex system of blood clotting must have a way to remove the clot once the wound has healed. How is this done? 17a. A blood protein, Plasminogen is activated by + - Pa to produce Plasmin. This acts like tiny chemical scissors which cuts up the Fibrin filaments of the clot. 17b. The rate at which the clot is broken up is controlled by yet another blood protein named Alpha 2 Antiplasm, which in turn inactivates Plasmin. One of the most important parts of this whole blood cloning machine is the ability it has to keep the clotting localized to the area of the wound and to stop the clotting cascade. What is the biggest killer of human beings? That's right, blood clots. Most heart attacks and strokes are caused by blood clots lodging. I believe the way your body shuts down the clotting cascade is as fascinating as the clotting process itself. 18. An%###!hrombin inactivates Activated Christmas, Activated Stuart and Thrombin. 19. Protein C is activated by Thrombin to produce Activated Protein C. 20. Activated Protein C inactivates Accelerin and Activated Antihemophilic. 21. Finally, Thrombomodulin which lines the inside of your blood vessels prevents Thrombin from activating Fibrinogen.

How the Body Works When the Skin is Cut When the skin is cut, blood vessels are also damaged and blood seeps into the wound cavity where it clots. The fibrin strands in the clot shrink, pulling the edges closer together. Later the cells in the cut edges start to multiply and migrate into the clot. At the same time, macrophages enter the wounded area and begin to remove dead cells, the blood clot, bacteria and any debris that has entered the cut. Capillaries enter the clot, to supply blood to the multiplying epidermal and dermal cells. All this occurs beneath the scab formed by the dried blood clot. When the cut has been repaired, the fibrin and collagen that have been deposited in the wound shrink to bind the two surfaces together. A pale fibrous scar is formed if the wound is large and the repairing tissue did not receive a blood supply. In cases of severe injury, surgical stitches may be needed to pull the cut surfaces together.

The Dynamics of Thrombin and Platelet Activation in Thrombosis and Inflammation Hybrid was selected by The Medicines Company and their agency Lifebrands USA to create a 10-minute animation centered on the role of thrombin in coagulation and intracoronary thrombosis and inflammation. The sequence featured here is from Chapter 1, which examines our current understanding of hemostasis and how it has evolved from the older "coagulation cascade" to a dynamic cell-based model that is more accurate - both physiologically and clinically. The main challenge for this scene was to cleanly and simply depict mature plaque bursting from inside an artery wall, the generation of thrombin at the site of disrupted plaque, platelet aggregation and activation, and the creation of fibrin, which leads to the formation of a clot. The client had very specific ideas for the way they wanted thrombin to be depicted, since its role was key to their story. http://www.hybridmedicalanimation.com

http://www.TakeBackYourHealth.com Many women suffer from the growth of uterine fibroids, benign tumors that develop in the womb. This common problem is one of the most common causes of their having hysterectomies. But surgery can be avoided if the fibroids are reduced or dissolved. Removing these growths, which consist of a protein called fibrin, is one of the applications of enzymes. Enzymes, of which the body makes a wide variety, are catalysts, causing actions of many kinds. Many are active in the digestive tract. Others reduce scar tissue and remove deposits in the blood vessels. Systemic enzymes can be taken by mouth as they are carried throughout the body and become active where they are needed. Fibrinolytic (fibrin eating) enzymes and cofactors are selected to attack excess fibrin build-up, the main components of fibroids, non-cancerous growths in the uterus. Correcting hormonal levels until they are in balance can significantly reduce the speed and intensity at which fibroids can grow. This allows the enzymes to soften, break-up and eventually dissolve abnormal tissue. The female hormone estrogen stimulates tissue growth especially in the estrogen-sensitive reproductive organs. The other female hormone, progesterone, makes tissue more fertile and helps to control the effect of estrogen. When a womans estrogen and progesterone production are in balance, normal menstrual cycles continue until menopause. Imbalance in natural hormone levels, as well as exposure to hormone-like substances, from pharmaceuticals and the environment, can cause disturbance, which may trigger abnormal tissue growth. This can lead to the development of fibroids. Progesterone naturally diminishes with age and supplementing dietary components will restore hormonal equilibrium.

FDA recently approved a new medical adhesive called Artiss to attach skin grafts onto burn patients. Artiss is made by Baxter Healthcare. Artiss has a lower thrombin concentration than other fibrin sealants, which gives surgeons more time to position the skin graft over a burn before the graft starts to adhere to the skin. In a multicenter clinical trial, Artiss was compared to surgical staples using two different wound sites on the same patient. The results showed that Artiss was comparable to staples in achieving complete wound closure. The most frequent adverse events, which were seen in both treatment groups, included bleeding and fluid collection in the tissues. Both of these events are common during skin grafting.

New three dimensional prosthetic device, lightweight, macroporosus, semiabsorbable, for large inguinal defect in young people(men). Confortable, no sutures, Quixil fibrin glue fixed

Previous dissection of the hernia sac, the wall defect is repared placing the underlay of an UHSoval semiabsorbable prosthesis deep onto the properitoneal space opening the trasversalis fascia.The onlay mesh will be spread out on inguinal floor and fixed out by fibrin glue Quixil.

Dr. Holger Berges talks about Omega 3 Fatty acid. ω−3 fatty acids (commonly spelled omega-3 fatty acids) are a family of polyunsaturated fatty acids which have in common a carbon-carbon double bond in the ω−3 position. September 8, 2004, the U.S. Food and Drug Administration gave "qualified health claim" status to ω−3 fatty acids, stating that "supportive but not conclusive research shows that consumption of EPA and DHA ω−3 fatty acids may reduce the risk of coronary heart disease." People with certain circulatory problems, such as varicose veins, benefit from fish oil. Fish oil stimulates blood circulation, increases the breakdown of fibrin and additionally has been shown to reduce blood pressure. There is strong scientific evidence, that ω−3 fatty acids significantly reduce blood triglyceride levels and regular intake reduces the risk of secondary and primary heart attack. Some benefits have been reported in conditions such as rheumatoid arthritis and cardiac arrhythmias. There is a promising preliminary evidence, that ω−3 fatty acids supplementation might be helpful in cases of depression and anxiety. Some research suggests that fish oil intake may reduce the risk of ischemic and thrombotic stroke. In addition ω−3 has shown to aid in other mental disorders such as aggression and ADHD.

Animation showing the process of hemostasis that occurs after damage to a blood vessel.

This video shows diabetic combined retinal detachment with an incomplete very shallow PVD, multiple vitreoretinal attachments, adherent hemorrhage with RD operated upon in the withoug pre surgical-anti-VEGF. Most of the dissection is performed using the vitreous cutter. The intraoperative problems faced such as recurrent bleeding, adherent clots, fibrin formation and steps at achieving hemostasis such as aspiration of the blood, gathering the clot to the bleeder site, clot dissection can be seen on the video. This video is in two parts because of its size

What you can see in the end is a piece of FIBRIN, a mate said. Don't be afraid I almost feel nothing (had drunk pastis before) Ce que vous voyez à la fin est un morceau de fibrine. Ne vous inquiétez pas je n'ai pas trop souffert pendant la vidéo, anesthésié que j'étais au pastis.

Intestinal resection, abdominal prosthetic repair with fibrin glue

John A. Hovanesian, MD, www.harvardeye.com explains how conjunctival chalasis can masquerade as dry eye. Discussion of diagnosis and surgical technique

http://www.proteolysis.org/ Coagulation is a complex process by which blood forms clots. The pathways are a series of reactions, in which a zymogen (inactive enzyme precursor) of a serine protease and its glycoprotein co-factor are activated to become active components that then catalyze the next reaction in the cascade, ultimately resulting in cross-linked fibrin. More on protease and substrates: http://cutdb.burnham.org