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Exogenous videos

Exogenous - 2001 Beldame Stakes

Exogenous, Spain and Flute battle to the wire

Exogenous Abuse

Mal Brough presents an ex-soldier's take on representative parliamentary democracy and racial discrimination. Because armies of all colours have enjoyed an historical association with sexual assault and land theft. Dedicated the memory of Stanley Bruce.

Exogenous - 2001 Gazelle Handicap

The late Exogenous wins with a nice burst of energy in the Gazelle Handicap. She badly injured herself in the paddock coming to the track for 2001 Breeders Cup Distaff and was sadly euthanized a few days later.

exogenous implementation

the implementation of exogeneity by means of subliminal occurrence of exemplary existential limina

Urophagia - Exogenous Bacteria

"Exogenous Bacteria Generates Inflammation in Connective Tissues" Urophagia rehearsal on Easter Sunday (04-08-2007). This is actually the 2nd time we have ever performed these songs together. Pretty unhinged. Sound Quality is pretty shitty too...Oh well. (DMT on Guitar/Vocs, Justin on drums.)

Exogenous - Lies

Exogenous played their original titled "Lies" at Singapore Band Challenge 2008

Exogenous Full Extension

At the Sasquatch Lounge in Glendale (L.A.), I take the innovative maneuver of deliberately full extending onto a nearby female while my good friend Nick Manz performs Meatloaf's "I Will Do Anything For Love (but I won't do that)". If you listen you can hear Nick yell "full extension!!!!" and you can also see the girl wipe the beer out of her eye.

D-Side - Speechless

add COMMENTS and RATINGS pls! This is one of UK boyband D-Side's video clips taken from their first album "Stronger Together". This is actually the only video clip that I have seen from D-Side in Australia.

Stem Cell Transfer

http://eppendorfna.com/CellTech The technique of introducing new genetic material into the germline of mammals has been a major development in biotechnology over the last decades. "Transgenic animals" are animals whose chromosomes contain stable, integrated copies of exogenous genes, additional copies of endogenous genes or gene constructs. They are frequently created by two different techniques: microinjection of DNA into the pronucleus of zygotes and injection of embryonic stem cells into blastocysts. This video covers injection of embryonic stem cells into blastocysts.

Innovation Survival - Innovation in Military, Warship Evolution

Google Tech Talks May, 14 2008 ABSTRACT The initial reaction and subsequent adoption patterns innovative designs receive often surprise their designers. But, regardless of the care and passion any designer embeds in a novel creation, the ultimate success metric can rest on the design's intended functional effectiveness and subsequent adoption rate on the design's ultimate proving ground. With warship design, well-intentioned, but ultimately misguided, design goals and applications can result in a harsh, swift, and unforgiving annihilation of the fledgling technology embodiment, its immediate attendants, as well as it's delivery platform. It is also true that failing to adopt a timely design innovation can have the same consequence. In either case, outcomes can prove catastrophic to participants. Here, reality, not opinion provides an acid test. This presentation focuses on warship evolution and a few of its several lessons for designers in nearly all vocations. From wooden warships to today's floating steel leviathans, Warship Evolution examines design innovators, their decisions, and exogenous events that shaped today's modern warships. As the anchor rises from the seabed and lights dim, prepare to lash yourself to a sturdy mast before traversing warship design history, safely out of harms way. Speaker: David Schwaderer W. David Schwaderer is a veteran Silicon Valley executive and entrepreneur. He is presently acting as the Symantec Technology Network Editor-In-Chief where he oversees corporate data protection technology and system security technical publishing as well as a monthly newsletter distributed to 120,000 global readers. David has a Masters Degree in Applied Mathematics from the California Institute of Technology and an MBA from the University of Southern California. Whenever possible, he lectures at universities such as Stanford and MIT and immerses Silicon Valley companies in his favorite subject - innovation. David has authored ten technical books and six commercial software programs for a variety of computing architectures using several different languages. His soon-to-be-published eleventh book follows ten years of research and is titled Innovation Survival - Concept, Courage and Change.

Bad Religion - Positive Aspect Of Negative Thinking lyrics

Words and music by J. Bentley The word endogenous means "arising from within", the opposite of exogenous. Grandiloquence is speech or writing marked by pompous or bombastic diction. [1] It is a combination of Latin word "grandis" (great) and "loqui" (to speak). Frivolous litigation, as used in colloquial and political terms in the United States, refers to lawsuits that are based on a theory that seems absurd, or where the claim results in damages that greatly exceed what one would expect from reading a brief summary of the case. Awards for medical malpractice are sometimes derided as frivolous (in this sense of meaning "excessive"). Positivism is a philosophy that states that the only authentic knowledge is knowledge that is based on actual sense experience. Such knowledge can only come from affirmation of theories through strict scientific method. Metaphysical speculation is avoided. It was developed by Auguste Comte (widely regarded as the first sociologist)[1] in the middle of the 19th century. In the early 20th century, logical positivism — a stricter and more logical version of Comte's basic thesis — sprang up in Vienna and grew to become one of the dominant movements in American and British philosophy. The positivist view is sometimes referred to as a "scientistic" ideology, and is often shared by technocrats[citation needed] who believe in the necessity of progress through scientific progress, and by naturalists, who argue that any method for gaining knowledge should be limited to natural, physical, and material approaches. Negativism may refer to: Pessimism, but rather specifically the philosophy that no knowledge is secure, and that we therefore know nothing.[1] a behavior of a patient not wanted to be moved, nor to move on command. It is a trait of catatonic stupor. Against the Grain is the fifth album (and seventh release overall) by punk rock band Bad Religion released on November 23, 1990.[1] This is the last album recorded with drummer Pete Finestone who left in 1991 to concentrate with The Fishermen and was replaced by the next drummer Bobby Schayer shortly before their 6th release, Generator. Along with the last two albums (1988's Suffer and 1989's No Control), Against the Grain is considered by many to be the band's greatest album, and it contains many songs that are constantly cited as the band's best, including "21st Century (Digital Boy)", "Anesthesia," "Walk Away," and "Modern Man."[citation needed] More than just an influentual album, Against The Grain gave many punk fans and many punk bands hope for the survival of punk in the 90s. Like Bad Religion's albums up to Generator, Against the Grain was remastered on April 6, 2004. The 1990 original version is now out of print. Against the Grain also marks the 10th anniversary of Bad Religion playing together after their formation.

G Protein Receptor

This animation describes what takes place with a G protein receptor. G Protein Coupled Receptors (GPCRs) are proteins embedded in the surface of cells. GPCRs comprise the largest superfamily of proteins in the body. More than 1,000 different GPCRs have been identified since the first receptors were cloned. These proteins receive chemical signals from outside the cell and pass the signal into the cell, so that the cell can respond to the signal. The structures of the endogenous ligands for GPCRs are exceptionally diverse. They include biogenic amines such as norephnephrine and serotonine, peptides, glycoproteins, lipids, nucleotides, ions, and proteases. The sensation of exogenous stimuli, such as light, odors, and taste, is also mediated by this class of receptors. Activation of the receptor causes an effector inside the cell to produce a second signal chemical, which eventually triggers the cell to react to the original external chemical signal. Andrea and Richard animated the signal process in this clip. A ligand, in this case Norepinepherine (NE), binds to the receptor and induces a conformational change. This conformational change activates the a/b complex. The complex is bound to GDP while it is inactive. GTP replaces GDP, thus activating the Alpha subunit. The activated Alpha subunit undergoes a conformational change and activates Adenylate Cyclase. Once the Adenylate Cyclase is activated, it is then able to convert ATP. The products of ATP conversion are c-AMP and two phosphate molecules. c-AMP is a second messenger used in many processes required for cell survival and growth. Future plans are to expand this animation to show the second messenger pathways, and further explain intracellular signaling in a variety of living processes. Created by: Andrea Dichele - Biomedical and Pharmaceutical Sciences StudentAndrea Dichele Class of 2006 Pharmacy Richard Wallace - Biomedical and Pharmaceutical Sciences StudentRichard Wallace Class of 2006 Pharmacy Doctor Rodgers - Biomedical and Pharmaceutical SciencesDr. Robert Rodgers Professor of Biomedical and Pharmaceutical Sciences Biomedical and Pharmaceutical Sciences College of Pharmacy Doctor Babson - Biomedical and Pharmaceutical SciencesDr. John Babson Associate Professor of Biomedical and Pharmaceutical Sciences College of Pharmacy

G Protein Receptor Take II

This animation describes what takes place with a G protein receptor. G Protein Coupled Receptors (GPCRs) are proteins embedded in the surface of cells. GPCRs comprise the largest superfamily of proteins in the body. More than 1,000 different GPCRs have been identified since the first receptors were cloned. These proteins receive chemical signals from outside the cell and pass the signal into the cell, so that the cell can respond to the signal. The structures of the endogenous ligands for GPCRs are exceptionally diverse. They include biogenic amines such as norephnephrine and serotonine, peptides, glycoproteins, lipids, nucleotides, ions, and proteases. The sensation of exogenous stimuli, such as light, odors, and taste, is also mediated by this class of receptors. Activation of the receptor causes an effector inside the cell to produce a second signal chemical, which eventually triggers the cell to react to the original external chemical signal. A ligand, in this case Norepinepherine (NE), binds to the receptor and induces a conformational change. This conformational change activates the a/b complex. The complex is bound to GDP while it is inactive. GTP replaces GDP, thus activating the Alpha subunit. The activated Alpha subunit undergoes a conformational change and activates Adenylate Cyclase. Once the Adenylate Cyclase is activated, it is then able to convert ATP. The products of ATP conversion are c-AMP and two phosphate molecules. c-AMP is a second messenger used in many processes required for cell survival and growth. Created by: Nelson Caetano Class of 2007 Pharmacy Dr. Jef Bratberg Clinical Assistant Professor of Pharmacy Practice College of Pharmacy

Mara Liasson Uses the Wrong Fancy Word on Fox News Sunday

Mara Liasson on Fox News Sunday, October 5, 2008

Transgenic

http://eppendorfna.com/CellTech The technique of introducing new genetic material into the germline of mammals has been a major development in biotechnology over the last decades. "Transgenic animals" are animals whose chromosomes contain stable, integrated copies of exogenous genes, additional copies of endogenous genes or gene constructs. They are frequently created by two different techniques: microinjection of DNA into the pronucleus of zygotes and injection of embryonic stem cells into blastocysts. This video covers microinjection of DNA into the pronucleus of zygotes.

www.DNATUBE.com Rnai interference video

http://www.dnatube.com RNA interference (also called "RNA-mediated interference", abbreviated RNAi) is a mechanism for RNA-guided regulation of gene expression in which double-stranded ribonucleic acid inhibits the expression of genes with complementary nucleotide sequences. Conserved in most eukaryotic organisms, the RNAi pathway is thought to have evolved as a form of innate immunity against viruses and also plays a major role in regulating development and genome maintenance. The RNAi pathway is initiated by the enzyme dicer, which cleaves double-stranded RNA (dsRNA) to short double-stranded fragments of 20--25 base pairs. One of the two strands of each fragment, known as the guide strand, is then incorporated into the RNA-induced silencing complex (RISC) and base-pairs with complementary sequences. The most well-studied outcome of this recognition event is a form of post-transcriptional gene silencing. This occurs when the guide strand base pairs with a messenger RNA (mRNA) molecule and induces degradation of the mRNA by argonaute, the catalytic component of the RISC complex. The short RNA fragments are known as small interfering RNA (siRNA) when they derive from exogenous sources and microRNA (miRNA) when they are produced from RNA-coding genes in the cell's own genome. The RNAi pathway has been particularly well-studied in certain model organisms such as the nematode worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the flowering plant Arabidopsis thaliana. The selective and robust effect of RNAi on gene expression makes it a valuable research tool, both in cell culture and in living organisms; synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. RNAi may also be used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Historically, RNA interference was known by other names, including post transcriptional gene silencing, transgene silencing, and quelling. Only after these apparently-unrelated processes were fully understood did it become clear that they all described the RNAi phenomenon. RNAi has also been confused with antisense suppression of gene expression, which does not act catalytically to degrade mRNA but instead involves single-stranded RNA fragments physically binding to mRNA and blocking translation. In 2006, Andrew Fire and Craig C. Mello shared the Nobel Prize in Physiology or Medicine for their work on RNA interference in the nematode worm C. elegans,[4] which they published in 1998

Louis Vierne - Finale from the 1st organ symphony

The organ of the parish church of San Vincenzo Martire in Nole (near Torino, Italy) was built by G. Gandini in 1922 and placed on a monumental organ loft at the western wall of the church. In the years 1999-2003 the organ was restored and enlarged to three manuals and 45 stops. As organist of the church, I designed these works to enhance the symphonic characteristics of the original organ. In the first years after the restoration the organ received a number of appreciations from many organists, both in Italy and abroad. Unfortunately, the 15 November 2006 the high church tower suddenly collapsed, destroying forever the historical organ, together with half of the church. Reconstruction works are now underway, but many years will elapse before to rebuild such an organ. I intended to publish some recordings featuring the destroyed instrument, but few recordings have been made in the few years after the restoration, most of them using low-quality equipment. So, I resolved to build a sort of virtual clone, using exogenous sound samples to reproduce as best as possible the original sound, still vivid in my memory. As building blocks I chose the sound samples from Shirokuma's Notre Dame de Budapest (IMO, the best symphonic organ library available now), mixing them in many ways to obtain the main sound features of the destroyed organ. The new stops are managed by a computer program and can be played in real-time by an ordinary II/P electric organ console. Also the original ambience effect has been modelled (the church is not rebuilt yet!). The result seems quite satisfactory. Of course, the sound of reed stops is a bit too full and tuned, the ambience effect is perhaps too warm, and so on, but... it is only a virtual organ. The clone is still at the experimental stage, but I was able to record some French-style Toccatas which I used to perform at Sunday Mass. The first example is the Vierne's Finale from the First Symphony, the glorious toccata-like movement that Vierne composed in one of the happiest periods of his tormented existence.

Dr. Ariel's Body Bliss Cleanse: PLASTICS DANGERS!

Dr. Ariel Policano chats about what you need to know about plastics in your world. Avoid those that are the most harmful! Find out which to avoid & which are OK. Find out more about Dr. Ariel at www.bodyblisscleanse.com

Midnight Croquet in the Rain

A highly surreal video of Dave and Richard: living manifestations of the constant strife of Oxford students to continue with their Oxonian pursuits despite unfavourable exogenous factors. Having discovered that playing croquet in the rain at a very late hour is nearly impossible, they invent a new game, with its rules apparently known only to Richard, and proceed to dance with umbrellas.

Man Claims he's Pregnant!

Labor of Love Transman Thomas Beatie gives The Advocate a first-person account of how it feels to be pregnant and carrying a child for his wife and himself. To our neighbors, my wife, Nancy, and I don't appear in the least unusual. To those in the quiet Oregon community where we live, we are viewed just as we are -- a happy couple deeply in love. Our desire to work hard, buy our first home, and start a family was nothing out of the ordinary. That is, until we decided that I would carry our child. I am transgender, legally male, and legally married to Nancy. Unlike those in same-sex marriages, domestic partnerships, or civil unions, Nancy and I are afforded the more than 1,100 federal rights of marriage. Sterilization is not a requirement for sex reassignment, so I decided to have chest reconstruction and testosterone therapy but kept my reproductive rights. Wanting to have a biological child is neither a male nor female desire, but a human desire. Ten years ago, when Nancy and I became a couple, the idea of us having a child was more dream than plan. I always wanted to have children. However, due to severe endometriosis 20 years ago, Nancy had to undergo a hysterectomy and is unable to carry a child. But after the success of our custom screen-printing business and a move from Hawaii to the Pacific Northwest two years ago, the timing finally seemed right. I stopped taking my bimonthly testosterone injections. It had been roughly eight years since I had my last menstrual cycle, so this wasn't a decision that I took lightly. My body regulated itself after about four months, and I didn't have to take any exogenous estrogen, progesterone, or fertility drugs to aid my pregnancy. Our situation sparks legal, political, and social unknowns. We have only begun experiencing opposition from people who are upset by our situation. Doctors have discriminated against us, turning us away due to their religious beliefs. Health care professionals have refused to call me by a male pronoun or recognize Nancy as my wife. Receptionists have laughed at us. Friends and family have been unsupportive; most of Nancy's family doesn't even know I'm transgender.

Antigen: protease degradation - PMAP

http://www.proteolysis.org/proteases Antigen processing is a biological process that prepares antigens for presentation to special cells of the immune system called T lymphocytes. This process involves two distinct pathways for processing of antigens from an organism's own (self) proteins or intracellular pathogens (e.g. viruses), or from phagocytosed pathogens (e.g. bacteria); subsequent presentation of these antigens on class I or class II MHC molecules is dependent on which pathway is used. Both MHC class I and II are required to bind antigen before they are stably expressed on a cell surface. The endogenous pathway is used to present cellular peptide fragments on the cell surface on MHC class I molecules. If a virus had infected the cell, viral peptides would also be presented, allowing the immune system to recognize and kill the infected cell. Worn out proteins within the cell become ubiquitinated, marking them for proteasome degradation. The exogenous pathway is utilized by professional antigen presenting cells to present peptides derived from proteins that the cell has endocytosed. The peptides are presented on MHC class II molecules. Proteins are endocytosed and degraded by acid-dependent proteases in endosomes; this process takes about an hour.

Pregnant Man ?! You what ?!

Thomas Beatie, a transgendered pregnant man, is ecstatic to welcome a daughter into the world this July. Thomas has a vagina, but he's legally male. Thomas is in a relationship with his wife Nancy, and he spoke to The Advocate about his journey to get knocked up. "Ten years ago, when Nancy and I became a couple, the idea of us having a child was more dream than plan. I always wanted to have children. However, due to severe endometriosis 20 years ago, Nancy had to undergo a hysterectomy and is unable to carry a child. But after the success of our custom screen-printing business and a move from Hawaii to the Pacific Northwest two years ago, the timing finally seemed right. I stopped taking my bimonthly testosterone injections. It had been roughly eight years since I had my last menstrual cycle, so this wasn't a decision that I took lightly. My body regulated itself after about four months, and I didn't have to take any exogenous estrogen, progesterone, or fertility drugs to aid my pregnancy." A year and many doctors later, Thomas got pregnant with triplets, but the pregnancy was ectopic. He lost his embryos and his right fallopian tube. His second pregnancy is a success and he's due on July 3, 2008.

Sleep Apnea Research

Sleep Apnea Research found at www.norml.com Click 'more' for details. One preclinical study is cited in the scientific literature investigating the role of cannabinoids on sleep-related apnea. Writing in the June 2002 issue of the journal of the American Academy of Sleep Medicine, researchers at the University of Illinois (at Chicago) Department of Medicine reported "potent suppression" of sleep-related apnea in rats administered either exogenous or endogenous cannabinoids.[1] Investigators reported that doses of delta-9-THC and the endocannabinoid oleamide each stabilized respiration during sleep, and blocked serotonin-induced exacerbation of sleep apnea in a statistically significant manner. No follow up investigations have taken place assessing the use of cannabinoids to treat this indication. However, several recent preclinical and clinical trials have reported on the use of THC, natural cannabis extracts, and endocannabinoids to induce sleep[2,3] and/or improve sleep quality.[4] Article full text at: http://www.norml.org/index.cfm?Group_ID=7016 Author: For patients and their physicians, let this report serve as a primer for those who are considering using or recommending medicinal cannabis. For others, let this report serve as an introduction to the broad range of emerging clinical applications for cannabis and its various compounds. Paul Armentano Deputy Director NORML | NORML Foundation Washington, DC January 24, 2008 * The author would like to acknowledge Drs. Dale Gieringer, Gregory Carter, Steven Karch, and Mitch Earleywine, as well as NORML interns John Lucy, Christopher Rasmussen, and Rita Bowles, for providing research assistance for this report. The NORML Foundation would also like to acknowledge Dale Gieringer, Paul Kuhn, and Richard Wolfe for their financial contributions toward the publication of this report. ** Important and timely publications such as this are only made possible when concerned citizens become involved with NORML. For more information on joining NORML or making a donation, please visit: http://www.norml.org/join. Tax deductible donations in support of NORML's public education campaigns should be made payable to the NORML Foundation. http://norml.com/index.cfm?Group_ID=7002 ________________________________________________________________ Prohibition: "Prohibition...goes beyond the bounds of reason in that it attempts to control a man's appetite by legislation and makes a crime out of things that are not crimes. A prohibition law strikes a blow at the very principles upon which our government was founded." -- Abraham Lincoln December 1840

Rnai

how is it discovered? http://WWW.DNATUBE.COM RNA interference (also called "RNA-mediated interference", abbreviated RNAi) is a mechanism for RNA-guided regulation of gene expression in which double-stranded ribonucleic acid inhibits the expression of genes with complementary nucleotide sequences. Conserved in most eukaryotic organisms, the RNAi pathway is thought to have evolved as a form of innate immunity against viruses and also plays a major role in regulating development and genome maintenance. The RNAi pathway is initiated by the enzyme dicer, which cleaves double-stranded RNA (dsRNA) to short double-stranded fragments of 20--25 base pairs. One of the two strands of each fragment, known as the guide strand, is then incorporated into the RNA-induced silencing complex (RISC) and base-pairs with complementary sequences. The most well-studied outcome of this recognition event is a form of post-transcriptional gene silencing. This occurs when the guide strand base pairs with a messenger RNA (mRNA) molecule and induces degradation of the mRNA by argonaute, the catalytic component of the RISC complex. The short RNA fragments are known as small interfering RNA (siRNA) when they derive from exogenous sources and microRNA (miRNA) when they are produced from RNA-coding genes in the cell's own genome. The RNAi pathway has been particularly well-studied in certain model organisms such as the nematode worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster, and the flowering plant Arabidopsis thaliana. The selective and robust effect of RNAi on gene expression makes it a valuable research tool, both in cell culture and in living organisms; synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. RNAi may also be used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Historically, RNA interference was known by other names, including post transcriptional gene silencing, transgene silencing, and quelling. Only after these apparently-unrelated processes were fully understood did it become clear that they all described the RNAi phenomenon. RNAi has also been confused with antisense suppression of gene expression, which does not act catalytically to degrade mRNA but instead involves single-stranded RNA fragments physically binding to mRNA and blocking translation. In 2006, Andrew Fire and Craig C. Mello shared the Nobel Prize in Physiology or Medicine for their work on RNA interference in the nematode worm C. elegans,[4] which they published in 1998.

Pregnant Man Thomas Beatie is Pregnant Again View, Oprah, Barbara Walters, Larry King

Pregnant Man Says He's Pregnant. Again! As seen on Oprah, View, 20/20, Barbara Walters, Larry King, CNN, Discovery Health, GMA, Insider. The man, who used to be a woman, was able to keep the reproductive organs he was born with. Pregnant Man Advocate http://www.advocate.com/exclusive_detail_ektid52947.asp Labor of Love Transman Thomas Beatie gives The Advocate a first-person account of how it feels to be pregnant and carrying a child for his wife and himself. Thomas Beatie From The Advocate March 25, 2008 Labor of Love To our neighbors, my wife, Nancy, and I don't appear in the least unusual. To those in the quiet Oregon community where we live, we are viewed just as we are -- a happy couple deeply in love. Our desire to work hard, buy our first home, and start a family was nothing out of the ordinary. That is, until we decided that I would carry our child. I am transgender, legally male, and legally married to Nancy. Unlike those in same-sex marriages, domestic partnerships, or civil unions, Nancy and I are afforded the more than 1,100 federal rights of marriage. Sterilization is not a requirement for sex reassignment, so I decided to have chest reconstruction and testosterone therapy but kept my reproductive rights. Wanting to have a biological child is neither a male nor female desire, but a human desire. Ten years ago, when Nancy and I became a couple, the idea of us having a child was more dream than plan. I always wanted to have children. However, due to severe endometriosis 20 years ago, Nancy had to undergo a hysterectomy and is unable to carry a child. But after the success of our custom screen-printing business and a move from Hawaii to the Pacific Northwest two years ago, the timing finally seemed right. I stopped taking my bimonthly testosterone injections. It had been roughly eight years since I had my last menstrual cycle, so this wasn't a decision that I took lightly. My body regulated itself after about four months, and I didn't have to take any exogenous estrogen, progesterone, or fertility drugs to aid my pregnancy. Our situation sparks legal, political, and social unknowns. We have only begun experiencing opposition from people who are upset by our situation. Doctors have discriminated against us, turning us away due to their religious beliefs. Health care professionals have refused to call me by a male pronoun or recognize Nancy as my wife. Receptionists have laughed at us. Friends and family have been unsupportive; most of Nancy's family doesn't even know I'm transgender. This whole process, from trying to get pregnant to being pregnant, has been a challenge for us. The first doctor we approached was a reproductive endocrinologist. He was shocked by our situation and told me to shave my facial hair. After a $300 consultation, he reluctantly performed my initial checkups. He then required us to see the clinic's psychologist to see if we were fit to bring a child into this world and consulted with the ethics board of his hospital. A few months and a couple thousand dollars later, he told us that he would no longer treat us, saying he and his staff felt uncomfortable working with "someone like me." In total, nine different doctors have been involved. This is why it took over one year to get access to a cryogenic sperm bank to purchase anonymous donor vials, and why Nancy and I eventually resorted to home insemination. When I finally got pregnant for the first time, I ended up having an ectopic pregnancy with triplets. It was a life-threatening event that required surgical intervention, resulting in the loss of all embryos and my right fallopian tube. When my brother found out about my loss, he said, "It's a good thing that happened. Who knows what kind of monster it would have been." On successfully getting pregnant a second time, we are proud to announce that this pregnancy is free of complications and our baby girl has a clean bill of health. We are happily awaiting her birth, with an estimated due date of July 3, 2008. How does it feel to be a pregnant man? Incredible. Despite the fact that my belly is growing with a new life inside me, I am stable and confident being the man that I am. In a technical sense I see myself as my own surrogate, though my gender identity as male is constant. To Nancy, I am her husband carrying our child -- I am so lucky to have such a loving, supportive wife. I will be my daughter's father, and Nancy will be her mother. We will be a family. Outside the local medical community, people don't know I'm five months' pregnant. But our situation ultimately will ask everyone to embrace the gamut of human possibility and to define for themselves what is normal. Man has baby Oprah Pregnant Man gives birth Baby girl Transsexual transgendered gay marriage lesbian rights sex change strange freak civil GOP Republican Democrat vagina penis