Blood Clotting Blood clotting takes place in a sequential process to prevent excessive blood loss from a wound. Normally, circulating blood contains red cells, platelets, plasma-clotting factors and fibrinogen, a soluble protein. Tissue-clotting factors lie trapped within cells surrounding each blood vessel. When an injury occurs, blood escapes from the broken vessel. Platelets aggregate at the site and partially plug the break. Tissue-clotting factors are released. The interaction of the platelets with plasma and tissue-clotting factors results in the conversion of fibrinogen into insoluble fibrin threads, which form a mesh across the break in the vessel wall. Blood cells and platelets become trapped in the mesh. The semisolid mass shrinks and a yellow fluid, serum, is pushed out, leaving the familiar dark red clot.

THE BLOOD CLOTTING CASCADE 1. A cut occurs and Hageman Factor sticks to the surface of cells near the wound. Bound Hageman Factor reacts with another enzyme called HMK to produce Activate Hageman. 2. Pre Kallikrein reacts with Activated Hageman to produce Kallikrein. 3. Hageman Factor also reacts with HMK and Kallikrein to form Activated Hageman. 4. PTA reacts with Activated Hageman and HMK to produce Activated PTA. 5. Christmas Factor reacts with Activated PTA and Convertin to produce Activated Christmas Factor. 6. Antihemophilic Factor is activated by Thrombin to produce Activated Antihemophilic Factor. 7. Stuart Factor reacts with Activated Christmas Factor and Activated Antihemophilic Factor to produce Activated Stuart Factor. 8. Proconvertin is activated by Activated Hageman Factor to produce Convertin. 9. When a cut occurs, Tissue Factor (which is only found outside of cells) is brought in near the wound where it reacts with Convertin and Stuart Factor to produce Activated Stuart Factor. (Note that step 9 involves an extrinsic process whereas step 7 is an intrinsic process.) 10. Proaccelerin is activated by Thrombin to produce Accelerin. 11a. GLU-Prothrombin reacts with Prothrombin Enzyme and Vitamin K to produce GLA-Prothrombin. (Note that Prothrombin cannot be activated in the GLU form so it must be formed into the GLA form. In this process ten amino acids must be changed from glutamate to gama carboxy glutamate.) 11b. GLA-Prothrombin is them able to bind to Calcium. This allows GLA-Prothrombin to stick to surfaces of cells. Only intact modified Calcium-Prothrombin Complex can bind to the cell membrane and be cleaved by Activated Stuart and Accelerin to produce Thrombin. 12. Prothrombin-Ca (bound to cell surface) is activated by Activated Stuart to produce Thrombin. 13. Prothrombin also reacts with Activated Stuart and Accelerin to produce Thrombin. (Step 13 is much faster than step 12.) 14. Fibrinogen is activated by Thrombin to produce Fibrin. Threads of Fibrin are the final clot. However, it would be more effective if the Fibrin threads could form more cross links with each other. 15. FSF (Fibrin Stabilizing Factor) is activated by Thrombin to form Activated FSF. 16. When Fibrin reacts with Activated FSF many more cross ties are made with other Fibrin filaments to form a more effective clot. Well now, I am wondering to myself whether you are experiencing frustration or intrigue, weariness or excitement. There are a lot of details but let me ask you a leading question. Is this intricate system something that man developed or is it something that man has discovered? Blood clotting is not an invention of man. It is the invention of either God or "Mother Nature" (i.e., it invented itself). Regardless of how you believe the clotting cascade came to be, (Accident or Design) the fact remains that blood clotting is a clear example of irreducible complexity which clearly indicates design. Let us next consider that this irreducibly complex system of blood clotting must have a way to remove the clot once the wound has healed. How is this done? 17a. A blood protein, Plasminogen is activated by + - Pa to produce Plasmin. This acts like tiny chemical scissors which cuts up the Fibrin filaments of the clot. 17b. The rate at which the clot is broken up is controlled by yet another blood protein named Alpha 2 Antiplasm, which in turn inactivates Plasmin. One of the most important parts of this whole blood cloning machine is the ability it has to keep the clotting localized to the area of the wound and to stop the clotting cascade. What is the biggest killer of human beings? That's right, blood clots. Most heart attacks and strokes are caused by blood clots lodging. I believe the way your body shuts down the clotting cascade is as fascinating as the clotting process itself. 18. An%###!hrombin inactivates Activated Christmas, Activated Stuart and Thrombin. 19. Protein C is activated by Thrombin to produce Activated Protein C. 20. Activated Protein C inactivates Accelerin and Activated Antihemophilic. 21. Finally, Thrombomodulin which lines the inside of your blood vessels prevents Thrombin from activating Fibrinogen.

Another pillar of intelligent design, the blood clotting system, is discussed by Dr. Ken Miller.

THE BLOOD CLOTTING CASCADE 1. A cut occurs and Hageman Factor sticks to the surface of cells near the wound. Bound Hageman Factor reacts with another enzyme called HMK to produce Activate Hageman. 2. Pre Kallikrein reacts with Activated Hageman to produce Kallikrein. 3. Hageman Factor also reacts with HMK and Kallikrein to form Activated Hageman. 4. PTA reacts with Activated Hageman and HMK to produce Activated PTA. 5. Christmas Factor reacts with Activated PTA and Convertin to produce Activated Christmas Factor. 6. Antihemophilic Factor is activated by Thrombin to produce Activated Antihemophilic Factor. 7. Stuart Factor reacts with Activated Christmas Factor and Activated Antihemophilic Factor to produce Activated Stuart Factor. 8. Proconvertin is activated by Activated Hageman Factor to produce Convertin. 9. When a cut occurs, Tissue Factor (which is only found outside of cells) is brought in near the wound where it reacts with Convertin and Stuart Factor to produce Activated Stuart Factor. (Note that step 9 involves an extrinsic process whereas step 7 is an intrinsic process.) 10. Proaccelerin is activated by Thrombin to produce Accelerin. 11a. GLU-Prothrombin reacts with Prothrombin Enzyme and Vitamin K to produce GLA-Prothrombin. (Note that Prothrombin cannot be activated in the GLU form so it must be formed into the GLA form. In this process ten amino acids must be changed from glutamate to gama carboxy glutamate.) 11b. GLA-Prothrombin is them able to bind to Calcium. This allows GLA-Prothrombin to stick to surfaces of cells. Only intact modified Calcium-Prothrombin Complex can bind to the cell membrane and be cleaved by Activated Stuart and Accelerin to produce Thrombin. 12. Prothrombin-Ca (bound to cell surface) is activated by Activated Stuart to produce Thrombin. 13. Prothrombin also reacts with Activated Stuart and Accelerin to produce Thrombin. (Step 13 is much faster than step 12.) 14. Fibrinogen is activated by Thrombin to produce Fibrin. Threads of Fibrin are the final clot. However, it would be more effective if the Fibrin threads could form more cross links with each other. 15. FSF (Fibrin Stabilizing Factor) is activated by Thrombin to form Activated FSF. 16. When Fibrin reacts with Activated FSF many more cross ties are made with other Fibrin filaments to form a more effective clot. Well now, I am wondering to myself whether you are experiencing frustration or intrigue, weariness or excitement. There are a lot of details but let me ask you a leading question. Is this intricate system something that man developed or is it something that man has discovered? Blood clotting is not an invention of man. It is the invention of either God or "Mother Nature" (i.e., it invented itself). Regardless of how you believe the clotting cascade came to be, (Accident or Design) the fact remains that blood clotting is a clear example of irreducible complexity which clearly indicates design. Let us next consider that this irreducibly complex system of blood clotting must have a way to remove the clot once the wound has healed. How is this done? 17a. A blood protein, Plasminogen is activated by + - Pa to produce Plasmin. This acts like tiny chemical scissors which cuts up the Fibrin filaments of the clot. 17b. The rate at which the clot is broken up is controlled by yet another blood protein named Alpha 2 Antiplasm, which in turn inactivates Plasmin. One of the most important parts of this whole blood cloning machine is the ability it has to keep the clotting localized to the area of the wound and to stop the clotting cascade. What is the biggest killer of human beings? That's right, blood clots. Most heart attacks and strokes are caused by blood clots lodging. I believe the way your body shuts down the clotting cascade is as fascinating as the clotting process itself. 18. An%###!hrombin inactivates Activated Christmas, Activated Stuart and Thrombin. 19. Protein C is activated by Thrombin to produce Activated Protein C. 20. Activated Protein C inactivates Accelerin and Activated Antihemophilic. 21. Finally, Thrombomodulin which lines the inside of your blood vessels prevents Thrombin from activating Fibrinogen.

For those who are not interested in Lab tests,, You don't have to seen this Video.. I'm Lab Student ,,i want to share my video :P ____________ This is done to measure the clotting time in a Patient's Plasma,, The normal range is 16 - 22 sec. testing the clotting factors is important to diagnose hemophilia and other bleeding disorder this patient is normal

cool video shot by US Army

pratice

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Most people have a blood-clotting factor ranging from 50 to 100 percent. Keith Longstreath has less than one percent. Keith, 13, was born with hemophilia, an inherited disorder that prevents the blood from clotting properly. A person with hemophilia has a deficiency of a blood protein, also called a 'clotting factor,' that is necessary for blood to clot and bleeding to stop. Keith's parents, Brian and Kenna, were in the military when he was first diagnosed. The doctors at the base did not specialize in hemophilia and the Longstreaths knew that there was a Hemophilia Treatment Center at The Children's Medical Center of Dayton that was conducting a clinical trial that offered free treatment product for hemophilia and asked for a hardship discharge from the military.

practice for out battleofthebands at pcs... the studio na pipnagpraktisan nmen : studio 108

QuikClot is a hemostasis agent that rapidly absorbs water molecules when it comes into contact with blood. The larger platelet and clotting factor molecules remain in the wound in a highly concentrated form, promoting rapid natural clotting and preventing severe blood loss.

Intelligent Design Arguments Refuted Why Intelligent Design is not science: http://youtube.com/watch?v=SRdVHuddA9g [5] Evolution of the eye: http://en.wikipedia.org/wiki/Evolution_of_the_eye http://www.2think.org/eye.shtml http://www.blackwellpublishing.com/ridley/a-z/Evolution_of_the_eye.asp http://www.pbs.org/wgbh/evolution/library/01/1/l_011_01.html http://www.youtube.com/watch?v=zI_oGu-2clE&feature=related http://www.youtube.com/watch?v=rUOpaFVgKPw Evolution of the bacteria flagellum: http://www.talkdesign.org/faqs/flagellum.html#conc http://en.wikipedia.org/wiki/Evolution_of_flagella http://www.health.adelaide.edu.au/Pharm/Musgrave/essays/flagella.htm Evolution of blood clotting: http://www.millerandlevine.com/km/evol/DI/clot/Clotting.html http://wiki.cotch.net/index.php/Blood_clotting http://www.youtube.com/watch?v=4K_WrqNiQoU Hey everyone. This is going to be a video in which I refute three popular Intelligent Design arguments. You can find a transcript of this in the video description, as well as all of my references. The first argument is "Intelligent Design is science, not creationism." I have already thoroughly refuted this claim in my previous video entitled "Why Intelligent Design is not science." You can find a link to this in the video description. The second argument ID proponents use is that irreducibly complex systems exist, and they serve as evidence for an intelligent designer. Before going into this claim, let's define irreducible complexity. Irreducible complexity (IC) is an argument that certain biological systems are too complex to have evolved from simpler predecessors through natural selection acting upon a series of beneficial naturally occurring mutations. [1] Before addressing the claims of this argument it's important to understand that this statement in itself contains two logical fallacies. The first logical fallacy is that it is an argument from ignorance. [2] ID advocates believe a natural explanation is absent or insufficient to account for these structures, therefore an intelligent agent must have designed them. You can see the obvious problem with this statement. An example to prove this point would be that ancient civilizations worshipped the sun as a deity because they lacked a natural explanation for the sun. Science has obviously advanced to a point where we no longer need a supernatural explanation for the sun. The second logical fallacy contained in this ID argument is a false dilemma. A false dilemma involves a situation in which only two alternatives are considered, when in fact there could be other options. [3] ID proponents state an intelligent agent is the only valid explanation to irreducible complex structures. This conclusion is based upon the assumption that current evolutionary theory and intelligent design are the only two valid models to explain life. Now that we have the logical fallacies sorted out, let's move on to the argument itself. The three most widely stated examples of irreducible structures are the eye, the bacteria flagellum, and blood clotting. [5] Unfortunately for ID advocates, we now how an understanding in how these complex structures evolved naturally in gradual steps. If you're interested in learning more, I'll be including some good articles and videos refuting each so called irreducible complex structure. [4] The third argument ID advocates claim is that intelligent design is infact falsifiable. ID advocates often use examples of how Ken Miller and others attempt to falsify so called "irreducibly complex" structures such as the Bacterial Flagellum, and use that as an example of how to falsify intelligent design. The problem with this argument is that the assumption that irreducible complex structures could have only been formed by an intelligent designer. As I pointed already, this is a logical fallacy in which they are arguing from ignorance. The only thing Ken Miller is doing is showing how irreducibly complexity is falsifiable, not ID itself. The Discovery institute even admits themselves that ID is not falsifiable." It's true that there's no way to falsify the bare assertion that a cosmic designer exists." [6] Well, that's all for this video. I hope you enjoyed and thank you for watching [1] http://en.wikipedia.org/wiki/Irreducible_complexity http://www.talkdesign.org/faqs/icdmyst/ICDmyst.html#intro [2] http://en.wikipedia.org/wiki/Argument_from_ignorance http://www.skepdic.com/ignorance.html [3] http://en.wikipedia.org/wiki/False_dichotomy http://www.nizkor.org/features/fallacies/false-dilemma.html [5] http://en.wikipedia.org/wiki/Irreducible_complexity#Stated_examples [6] http://www.evolutionnews.org/2006/01/intelligent_design_is_empirica.html

2D animation from MediVisuals Inc. showing how clots normally form and dissolve as well as how the drug Amicar acts globally to create a hypercoagulable state that disables dissolving factors and results in blockage of the right middle cerebral artery. Please visit our website at http://www.medivisuals.com

Visit http://Bayer.VTENews.ca for more information. Toronto, Ontario - September 16, 2008 Today, Canada became the first country to approve Xarelto® (rivaroxaban), the first in a new class of anticoagulants, for the prevention of venous thromboembolic events (VTE), or blood clots, in patients who have undergone elective total hip or total knee replacement surgery. As a direct factor Xa inhibitor, Xarelto targets an enzyme that acts as a switch to control clotting, reducing the risk of potentially deadly blood clots that can form post hip or knee replacement surgery.

Short clip from VCU video outlining a new blood clotting agent

Overview of Disseminated Intravascular Coagulation (DIC). How systemic inflammation causes the clotting and bleeding syndrome of DIC. http://www.101-nursing-tips.com

www.heartandstroke.ca -- Video from Heart and Stroke Foundation of Canada explaining stroke, and the clot busting drugs that can be used to help reverse the effects of stroke. This is what happens when you put your heart into it.

Fibrin, one of the primary clotting agents, should "turn on" in the case of an injury to help clot your blood. Then turn off when the bleeding has stopped. In the elderly and those with chronic health conditions, however, these white stringy fibers develop during the healing process, often forming scar tissue. This excess fibrin—from scars, surgeries, or arterial sclerotic plaque (scar tissues of the arteries)—can cause the blood to thicken. The thickened blood acts like a "sludge," preventing oxygen and nutrients from reaching the cells and creating a breeding ground for infectious agents. Thick blood can also be caused by chronic infection, inflammation, and heavy metal toxicity. So keeping your blood—your body's "river of life"—clean and flowing smoothly without infection is vital to staying healthy and feeling better. Research over the past 25 years has shown that Nattokinase—a traditional Japanese folk medicine from Natto—helps strengthen the heart and thin thickened blood by dissolving excess fibrin in the circulatory system. Kinase Plus, a proprietary enzyme blend based on the powerful fibrin-reducing properties of Natto, contains 2,000 fibrinolytic units (FU) in each capsule. More potent than other nattokinase supplements, Kinase Plus helps dissolve fibrin build-up to keep your blood flowing freely and smoothly. And because Kinase Plus is so effective, you only need to take up to three capsules a day to feel better—not the six or 12 suggested for other nattokinase supplements.

View the Hemophilia of Georgia video to learn more about Hemophilia of Georgia's programs and services.

Kaden had a rough start from the beginning. I was diagnosed with 2 rare blood clotting disorders at 5 weeks, he had a down syndrome scare and nuchal translucency thickening at 12 weeks. At 16 weeks we found out about the CDH and at 20 weeks he had bilateral cysts on his brain. Kaden fought hard and by the tie he was born he only had CDH, The most life threatening of all. I won't lie and say that we did not think of saving Kaden all the pain by ending his life in utero, but we decided we wanted to give him every chance we could. I transferred O.B.'s 5 times, and we transferred hospitals 3 times. We wish things could have been different but we know everything happens for a reason. God is lucky to have an Angle like Kaden.

A tribute to a very special little boy with Down syndrome who fought a courageous battle against an auto-immune clotting disorder which took his life.

Researchers believe that a spray containing the clotting agent from brown snake venom could eventually be used by emergency response teams to save the lives of trauma victims. Tune in on Sunday, June 24 at 8 p.m. (ET) on PBS (check local listings), when the NATURE series presents The Venom Cure. The Venom Cure illustrates how some of the animals we fear most may one day soon be helping us solve or alleviate a wide range of life-threatening medical problems. For more information, go to http://www.pbs.org/wnet/nature/venomcure/

The video provides another dimension into the ever expanding research and development in the field of bio-pharma.

This video was produced by the APS Foundation of America, Inc. The APSFA can be located at http://www.apsfa.org. APS is associated with recurrent clotting events (thrombosis) including premature stroke, repeated miscarriages, phlebitis, venous thrombosis (clot in the vein) and pulmonary thromboembolism (blockage of an artery found in the lung due to a clot that has traveled from a vein). It is also associated with low platelet or blood elements that prevent bleeding. Recently, however, even more disease states have been linked with APL including premature heart attack, migraine headaches, various cardiac valvular abnormalities, skin lesions, abnormal movement/chorea, diseases that mimic multiple sclerosis, vascular diseases of the eye that can lead to visual loss and blindness. The APS Foundation of America, Inc. is the only United States nonprofit health agency dedicated to bringing national awareness to Antiphospholipid Antibody Syndrome (APS), the major cause of multiple miscarriages, thrombosis, young strokes and heart attacks. We are a volunteer run, community based 501(c)3 non-profit Public Charity organization and is dedicated to fostering and facilitating joint efforts in the areas of education, support, public awareness, research and patient services. Their URL is http://www.apsfa.org The APS Friends and Support Forum at http://www.apsforum.com . This is an open forum for people who have Antiphospholipid Antibody Syndrome, friends, family, and caregivers. There are many ways you can help the APS Foundation of America, Inc. You can volunteer your time and talents such as in the area of fundraising, advocacy, finance, or support group experiences, donate money or purchase APS gear through our webpage at http://www.apsfa.org or through our Café Press at http://www.cafepress.com/apsfoundation. Keywords: APSFA, APS, Foundation, antiphospholipid antibody syndrome, lupus, stroke, dvt, pe, thrombosis, clot, migraine, hughes, syndrome, miscarriage, anticoagulant, heart attack, vertigo

This lecture is an overview of the components of blood and their major functions. It also, briefly describes the process of blood clotting.