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'Hugh Percy, 1st Duke of Northumberland' KG PC (c. 1714 – June 6 1786) was the son of Langdale Smithson.
The Duke was born with the name 'Hugh Smithson' but changed the family surname to Percy when he married Elizabeth Seymour, daughter of Algernon Seymour, 7th Duke of Somerset, on 16 July 1740. She was ''Baroness Percy'' in her own right, and indirect heiress of the Percy family, which was one of the leading landowning families of England, and had previously held the Earldom of Northumberland for several centuries. They had two children:

★ Hugh Percy, 2nd Duke of Northumberland (1742–1817)

★ Algernon Percy, 1st Earl of Beverley (1750–1830)
The remainder of the Duke of Somerset's title, ''Earl of Northumberland'' passed to Hugh Percy as the husband of his daughter when he died. In 1766, the earl was created 1st Duke of Northumberland and was created Baron Lovaine on 28 June 1784, with a special remainder in favour of his younger son, Algernon. He was created a Knight of the Order of the Garter (K.G.) in 1756 and a Privy Counsellor in 1762.
The duke and duchess were prominent patrons of Robert Adam for neoclassical interiors in the Jacobean mansion Northumberland House, the London seat of the Earls of Northumberland; it was demolished ca. 1870–1871, in connection with the creation of Trafalgar Square. Remnants of the Northumberland House Glass Drawing-Room are preserved at the Victoria and Albert Museum. The greater Adam interiors for the Duke are at Syon House, executed in the 1760s. At Alnwick Castle, Northumberland, the Duke employed James Wyatt, whose work has been effaced by later remodelings.
His illegitimate son (by Elizabeth Hungerford Keate), James Smithson (1765–1829), is famed for having made the founding bequest for the Smithsonian Institution in Washington, D.C.