A 'sinusoid' is a small
blood vessel similar to a
capillary but with a
discontinuous endothelium.
Sinusoids are found in the
liver,
lymphoid tissue,
endocrine organs, and
hematopoietic organs such as the
bone marrow and the
spleen.
Their highly permeable nature is due to larger inter-cellular clefts, fewer tight junctions, and discontinous
endothelial cells, allows small and medium-sized proteins such as
albumin to enter and leave the blood stream. Some spaces are large enough for blood cells to pass.
The sinusoids of the liver are of particular importance to the function of that organ, and are discussed in more detail at
liver sinusoid.