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'Sean O'Brien' may refer to:

★ Sean O'Brien - human rights lawyer at the Center for Civil and Human Rights at the Notre Dame Law School

★ Sean O'Brien - American death penalty attorney who practices before the US Supreme Court, professor at the University of Missouri-Kansas City School of Law, prolific writer on capital punishment

★ Sean O'Brien (writer)

★ Sean O'Brien (politician) - member of the South Dakota State House of Representatives

★ Sean O'Brien (scientist) - co-discoverer of Buckminster Fullerene and the Fullerenes

★ Seán O'Brien, a noted Gaelic footballer

★ Sean O'Brien, Australian accordionist, ex Riverdance dancer and keyboardist