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'Pico' may refer to:

★ pico-, a prefix in the International System of Units (SI) denoting a factor of 10^-12.

★ Pico (F-Zero), one of the four original pilots in the ''F-Zero'' video game series.

★ Pico (image editor), an image editor developed at Bell Labs.

★ Pico (programming language), developed at Vrije Universiteit Brussel.

★ PICO (search strategy), a search strategy for evidence based medicine.

★ Pico (text editor), a text editor originally designed for composing e-mail for Pine.

★ Pico de gallo, a salsa made from fresh vegetables, especially tomatoes, onions, and peppers.

★ Sega Pico, a video game system designed for young children.

★ Laser Pico, a sailing dinghy for one or two people.

★ Bd. of Educ. v. Pico, 457 U.S. 853.

★ PICO, Physical Intervention in Computational Optimization, An interactive table top.
'People:'

★ Andrés Pico (1810-1876), Mexican general, and governor of pre-statehood California; brother of Pío Pico.

★ Pío Pico (1801–1894), Mexican politician, entrepreneur and governor of pre-statehood California; brother of Andrés Pico.

★ Pico Iyer (b. 1957), British journalist, essayist, and author.

★ Giovanni Pico della Mirandola (1463-1494), Italian renaissance author and philosopher.
'Fiction:'

★ Pico, a character created by the comedy team The Jerky Boys.

★ Pico, the protagonist of , a shotacon anime

★ Pico, the mascot of the website Newgrounds.

★ Pico de Paperis, the Italian name for the Disney character, Ludwig von Drake.
'Places:'

★ Pico, Italy, Frosinone province.

★ Pico, Vila Verde, Portugal.

★ Pico Boulevard, a street in Los Angeles, California.

★ Pico Island, Azores.

★ Pico da Pedra, Ribeira Grande, Azores.

★ Pico do Fogo, the indigenous name for Mount Fogo volcano on Fogo Island, Cape Verde.

★ Pico Blanco Scout Reservation, California.

★ Mons Pico, a Lunar mountain located in Mare Imbrium.

★ Pico Mountain, Killington Ski Resort.
'See also:'

★ Piko

★ Pica (disambiguation)

★ PICA (disambiguation)

★ Pika

★ Picus

★ Picus (disambiguation)

★ Ed Picco

★ Picco pipe

★ Piccio

★ Piccolo

★ Piccolo (disambiguation)