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'Paromomycin sulfate' (brand name 'Humatin'®) is a drug that fights intestinal infections such as cryptosporidiosis and amoeba infection, or amoebiasis and was developed as a therapeutic against visceral leishmaniasis by the Institute for OneWorld Health. Paromomycin was granted orphan drug status in 2005^[1] and was approved by the Drug Controller General of India in September 2006 for treatment visceral leishmaniasis.^[1]
Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA.^[3]

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3. Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site, , Quentin, Vicens, Structure, 2001