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'Oswegatchie' may refer to:
In New York:

★ Oswegatchie, New York, a town in St. Lawrence County

★ Oswegatchie River, a tributary of the Saint Lawrence River

★ Oswegatchie tribe, a native people of northern New York

★ Fort Oswegatchie, subsequent name of Fort de La Présentation

★ Oswegatchie Corners, a location in the town of Diana, New York