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'New Madrid' may refer to:

★ New Madrid County, Missouri, a county located in the U.S. state of Missouri

★ New Madrid, Missouri, a city in New Madrid County, Missouri on the Mississippi River

★ New Madrid Seismic Zone, a major seismic zone located in the Southern United States and Midwestern United States

★ New Madrid earthquake, a series of three earthquakes from 1811-1812 centered around New Madrid.

★ "New Madrid", a song by Uncle Tupelo from their 1993 album ''Anodyne''