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'Nerve growth factor' ('NGF'), is a small secreted protein which induces the differentiation and survival of particular target neurons (nerve cells). It is perhaps the prototypical growth factor, in that it is one of the first to be described - that work by Rita Levi-Montalcini and Stanley Cohen was rewarded with a Nobel Prize.

Contents

Function

Receptor binding mechanism

TrkA, B, and C receptors

LNGFR receptor

History

Cultural significance

See also

References

External links

Function

NGF is critical for the survival and maintenance of sympathic and sensory neurons.
NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. There is some data that shows that NGF can be transported from the axon tip to soma, but it is unclear if it this is necessary for effective cell signalling; in fact there is data showing that it is not. What is clear is that NGF binding and activation of TrkA is required for NGF-mediated neuronal survival and differentiation.

Receptor binding mechanism

NGF binds at least two receptors on the surface of cells which are capable of responding to this growth factor, TrkA (pronounced "Track A") and the LNGFR (for "low affinity nerve growth factor receptor").

TrkA, B, and C receptors

TrkA is a receptor tyrosine kinase (meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling).
There are other related Trk receptors (TrkB and TrkC), and there are other neurotrophic factors structurally related to NGF (BDNF, NT-3, and NT-4)

★ TrkA mediates the effects of NGF

★ TrkB binds and is activated by BDNF, NT-4, and NT-3

★ TrkC binds and is activated only by NT-3

LNGFR receptor

The other NGF receptor, the LNGFR, (for Low affinity nerve growth factor receptor, commonly known as "p75", plays a less clear role.
LNGFR binds and serves as a "sink" for neurotrophins. Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity - since they have a higher "microconcentration" of the neurotrophin.
However, although NGF has been classically described as promoting neuron survival and differentiation, research performed in the early 2000's suggest that NGF with its prodomain attached (proNGF) can elicit apoptosis of cells that are positive for the LNGFR and negative for TrkA.^[1]
Secreted proNGF has been demonstrated in a variety of neuronal and non-neuronal cell populations. It has been proposed that secreted proNGF can elicit neuron death in a variety of neurodegenerative conditions, including Alzheimers disease, following the observation of an increase of proNGF in the nucleus basalis of postmortem Alzheimer's brains.

History

Stanley Cohen and Rita Levi-Montalcini won the 1986 Nobel Prize in Physiology or Medicine for their discovery of NGF and other growth factors.^[2][3][4]

Cultural significance

NGF has been tied to human romantic love.^[5][6][7]
It has also been tied to Alzheimer's disease.^[8][9][10]

See also

★ Protein targeting

★ Nervous System

References

1. Jekyll-Hyde neurotrophins: the story of proNGF, Ibáñez C, , , Trends Neurosci, 2002
2. The 1986 Nobel Prize in Physiology or Medicine for discoveries of growth factors
3. Presentation Speech by Professor Kerstin Hall The Nobel Prize in Physiology or Medicine 1986
4. Rita Levi-Montalcini – Nobel Lecture
5. Raised plasma nerve growth factor levels associated with early-stage romantic love, Emanuele E, Politi P, Bianchi M, Minoretti P, Bertona M, Geroldi D, , , Psychoneuroendocrinology, 2006 link
6. "NGF" gives passionate lovers just one year, Reuters, November 29, 2005.
7. John Harris Is love just a chemical?, Guardian, November 29, 2005.
8. The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease, Counts S, Mufson E, , , J Neuropathol Exp Neurol, 2005
9. Dissecting the diverse actions of pro- and mature neurotrophins, Hempstead B, , , Curr Alzheimer Res, 2006
10. Clinical relevance of the neurotrophins and their receptors, Allen S, Dawbarn D, , , Clin Sci (Lond), 2006

External links

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