'Interleukin-3' ('IL-3') is an
interleukin, a type of biological signal (
cytokine) that can improve the body's natural response to disease as part of the immune system.
IL-3 stimulates the proliferation of hematopoietic
pluripotent progenitor cells. It is secreted by activated
T cells to support growth and differentiation of T cells from the bone marrow in an immune response. The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on
chromosome 5, only 9 kilobases from the
GM-CSF gene, and its function is quite similar to GM-CSF.
External link
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Structure, Function, and Clinical Applications of Interleukin-3