'Evolutionary medicine' or 'Darwinian medicine' is the field of knowledge that integrates
medicine with
evolutionary biology, more specifically with the
adaptationist program.
The theory of evolution suggests that all living beings are the result of a process known as
evolution by
natural selection. This process occurs whenever genetically influenced variation among a
population affects
reproductive success. For instance, a genetic
mutation that causes greater vulnerability to
disease will decrease in
frequency compared to its alternative
allele that causes greater resistance to disease.
It is thought that evolution by natural selection produced the functional design observed in living beings, known as
adaptations, and therefore sickness and disease can be explained through a cost v. benefit analysis of physiological function. Understanding evolutionary design helps medicical researchers explain phenomena like: infections, injury, intoxication, genetic diseases, aging, allergy, problems during childbirth, cancer and mental disorders.
A well-known example of the application of evolutionary medicine is the study of the
evolutionary arms race between the body's defenses and
pathogens. Other examples include human populations that have certain disease susceptibilities that arose as comprises allowing their survival. These include,
sickle cell anemia protecting against
malaria and
hemochromatosis protecting against the
bubonic plague.
Among the researchers in this field who have received recent recognition are: Rainer H. Straub,
Paul W. Ewald,
Randolph M. Nesse and
George C. Williams.
Bibliography
★
Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases, , RH., Straub, Faseb J, 2003
★
A science of the individual: Implications for a medical school curriculum, , B., Childs, Annual Review of Genomics and Human Genetics, 2005
★
Toward an evolutionary taxonomy of treatable conditions, , L., Cosmides, Journal of Abnormal Psychology, 1999
★
Evolution of Infectious Disease, , P. W., Ewald, Oxford University Press, 1996,
★
Darwinian medicine: applications of evolutionary biology for veterinarians, , E. K., LeGrand, Canadian Veterinary Journal, 2002
★
Why We Get Sick: The New Science of Darwinian Medicine, , R. M., Nesse, , ,
★
Disease versus disease: how one disease may ameliorate another, , E. R., Stiehm, Pediatrics, 2006
★
Evolutionary Medicine, , W. R., Trevathan, Oxford University Press, 1999,
★
The dawn of Darwinian medicine, , G. C., Williams, Quarterly Review of Biology, 1991
See also
★
Evolutionary physiology
★
Evolutionary psychology
External links
★
"Evolution and Medicine" website
★ http://www.people.virginia.edu/~rjh9u/darwmed.html
★ http://www.chester.ac.uk/~sjlewis/EM/