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'Deoxyribonuclease I' cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. DNase I is also a polymerization initiator for the cytoskeletal protein actin. It has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis.

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