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The 'Real Colegio de Santa Cruz' in Tlatelolco, Mexico, was the first European school of higher learning in the Americas. Built by the Franciscan order at the initiative of Viceroy Antonio de Mendoza and Bishop Juan de Zumárraga on the site of an Aztec school for the children of nobles (in Nahuatl: Calmecac), it was inaugurated on January 6, 1536; however, it had been a functioning school since August 8, 1533. In 1546 the Franciscan order gave the responsibilities of the administration of the school to the indigenous priests who had been educated there but by 1605 the school ceased to have governmental support and by the mid seventeenth century it was abandoned and in ruins. In modern Mexico city the Plaza de las Tres Culturas, close to the location of the ''Colegio'', commemorates this particularly interesting part of the cultural history of Mexico.
The original purpose of the ''colegio'' was to educate an indigenous priesthood, and so pupils were selected from the most prestigious families of the Aztec ruling class. They were taught in Nahuatl, Spanish and Latin and also learned the basics of Greek as well as crafts such as illumination, bookbinding and European art. Among the teachers were notable scholars and grammarians such as Andrés de Olmos, Alonso de Molina and Bernardino de Sahagún, all of whom have made important contributions to the study of both the Classical Nahuatl language and the ethnography and anthropology of Mesoamerica. Also Fray Juan de Torquemada served as a teacher and administrator at the Colegio. When recollecting historical and ethnographical information for the elaboration of the Florentine Codex, Sahagún used his trilingual students to elicit information from the Aztec elders and to transcribe it in Spanish and Nahuatl and to illuminate the manuscripts. The Nahua botanist Martín de la Cruz who wrote the Libellus de Medicinalibus Indorum Herbis was also educated at the Colegio.

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★ Maxwell, Judith M, and Craig A Hanson, 1992, "Introduction" ''Of the Manner of Speaking That the Old Ones Had: Arte Para aprender la Lengua Mexicana 1547''. University of Utah Press, Salt Lake City.

★ Mathes, Michael, 1985, "''The Americas' first academic library Santa Cruz de Tlatelolco''", Sacramento, Califoria State Library.