 | MAKING A COILED WIRE BEAD--2 Corrine Gurry demonstrates how to make a coil spring bead and to coil yarn on wire using the Professional Deluxe Coiling Gizmo®. This tool was invented by LeRoy Goertz. Order it online at www.coilinggizmo.com. |
 | Flag Cable Line with 360' rotational and windchimes setup Filmed at two different times. At night... And in the day time. Use for the ultra light red line is gonna be either for extra flags or smaller wind chimes. It consists of 3 coiled key rings measuring almost 50 ft. long. |
 | Kinesin Transport Protein ***From Wikipedia*** Function In the cell, small molecules such as gases and glucose diffuse to where they are needed. Large molecules synthesized in the cell body, intracellular components such as vesicles, and organelles such as mitochondria are too large (and the cytosol too crowded) to diffuse to their destinations. Most kinesins transport such cargo about the cell by walking unidirectionally along microtubule tracks hydrolysing one molecule of adenosine triphosphate (ATP) at each step. It was thought that ATP hydrolysis powered the kinesin walk but it now seems that the force of binding to the microtubule is what pulls the cargo along while the binding of ATP assists the direction of motion. Structure The typical kinesin is a protein dimer consisting of two heavy chains and two light chains. The heavy chains comprise a globular head (the motor domain) connected via a short, flexible neck linker to the stalk - a long, central coiled-coil region - that ends in a tail region formed with a light-chain. The stalks intertwine to form the kinesin dimer. Cargo binds to the tail while the twin heads alternately bind the microtubule as the kinesin pulls the cargo along. The heads will hydrolyze 2 ATP molecules per step. Polarity Motor proteins travel in a specific direction along a microtubule. This is because the microtubule is polar, the heads only bind to the microtubule in one orientation, and ATP hydrolysis drives the molecule in one direction. Most kinesins walk towards the positive end of a microtubule which, in most cells, entails transporting cargo from the centre of the cell towards the periphery. This form of transport is known as anterograde transport. Some kinesins {EG5}, and a different type of motor protein known as dyneins, move towards the minus end of the microtubule. Thus they transport cargo from the periphery of the cell towards the centre. This is known as retrograde transport. These motors have a different morphology: their structure is such that they move in the opposite direction though the directional principle is the same as for the rest of the family. Proposed mechanisms Kinesin accomplishes transport by essentially "walking" along a microtubule. Two mechanisms have been proposed to explain how this movement occurs. * In the "hand-over-hand" mechanism, the kinesin heads step over one another, alternating the lead position. * In the "inchworm" mechanism, one kinesin head always leads, moving forward a step before the trailing head catches up. Despite some remaining controversy, mounting academic evidence points towards the symmetric inchworm mechanism as being more likely. Asters and assembly In recent years, it has been found that microtubule-based molecular motors (including a number of kinesins) have a role in mitosis (cell division). The mechanism by which the cytoskeleton of the daughter cell separates from that of the mother cell was unclear. It seems that motors organize the two separate microtubule asters into a metastable structure independent of any external positional cues. This self-organization is in turn dependent on the directionality of the motors as well as their processivity (ability to walk). Thus motors are necessary for the formation of the mitotic spindle assemblies that perform chromosome separation. Specifically, proteins from the Kinesin 13 family act as regulators of microtubule dynamics. The prototypical member of this family is MCAK (formerly Kif2C, XKCM1, Gene KIF2C) which acts at the ends of microtubule polymers to depolymerize them. The function of MCAK in cells and its mechanism in vitro is currently being investigated by numerous labs. |
 | Crafty Quickies™: How to Make a Coil Top Dangle Crafty Quickies offer simple to follow craft basics instruction for the time and technically challenged. The Impatient Crafter™ Margot Potter hosts these quick and easy tutorials that show you how to get it right the first time. In this video she shows how to make a coiled top dangle. |
 | Coil # 3 Trap Set This video shows how to set a #3 Bridger Coil Trap. |
 | Spinning a coiled Yarn Me spinning on my Babe Fiber Garden ST wheel. It's a spinning wheel made from PVC pipes and a wheel chair wheel :) To spin a coil yarn, first spin a slightly over-spun single, then use a thin yarn or thread (make sure its STRONG) and hold the thread still as you let the single wrap around the thread. I stop after two wheel turns to untwist the core thread. This makes sure the thread doesn't get over spun and break. Before I untwist the core, I slide the singles wrapped around up close to create the coils. Make sure not to push them too tightly together, otherwise your coils will end up very tight and stiff. You want them nice and springy and squishy :o) The background song is Better In Time by Leona Lewis, from her Spirit Album. |
 | Cutting Coil 1 CTU 9 Cutting Coiled Tubing with our Hydraulic Cutter. With Chuck's snot slinging cutter. |
 | Knot Tying & Climbing Rope Coiling : How to Coil a Rope Coiling utility rope does not have to be as carefully coiled as climbing rope. Learn how to coil a campsite rope and other non-climbing ropes in this free video. |
 | Integrin-Collagen binding model, PMAP http://www.proteolysis.org Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals, making up about 50% of the whole-body protein content. The tropocollagen or "collagen molecule" is a subunit of larger collagen aggregates such as fibrils. It is approximately 300 nm long and 1.5 nm in diameter, made up of three polypeptide strands (called alpha peptides), each possessing the conformation of a left-handed helix (its name is not to be confused with the commonly occurring alpha helix, a right-handed structure). These three left-handed helices are twisted together into a right-handed coiled coil, a triple helix or "super helix", a cooperative quaternary structure stabilized by numerous hydrogen bonds. Design & production: Kosi Gramatikoff, PhD & Robert Liddington, PhD |
 | Memory Wire Bracelet Want a fast and easy way to create a beaded coil bracelet? Memory Wire is the answer! This tempered wire holds it's coiled shape making this medium fun to create and work with. It is so versatile, you can make one coil or multiple coils! I will demonstrate a multiple coiled bracelet using some simple beads, that create a rich, warm wrap for the wrist! www.auntiesbeads.com |
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