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'Cacique' or 'Cazique' is a term applied to the pre-Columbian chiefs or leaders, predominantly in Latin America.
'Cacique' may also refer to:

★ Cacique (bird), a group of birds in the blackbird family

★ Cacique (rum), a brand of rum from Venezuela

★ A rank of nobility defined under the 1669 ''Fundamental Constitutions of Carolina''

★ Cacique Nutibara Bloc, a Colombian paramilitary bloc, c. 2002 - 2005

★ Estadio Cacique Diriangén, a multi-use stadium in Diriamba, Nicaragua

★ ''Cacique Bandeira'', a 1975 Argentine film

★ "Cacique of the South", nickname of Cirilo Vázquez, a Mexican cattle rancher and businessman