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NOD2 (nucleotide-binding oligomerization domain containing 2) is a protein, also known as the caspase recruitment domain family, member 15 (CARD15), which plays an important role in the immune system. It is an intracellular pattern recognition receptor, which is similar in structure to resistant proteins of plants and recognizes molecules containing the specific structure called muramyl dipeptide (MDP) that is found in certain bacteria.^[1]
The ''NOD2'' gene is linked to inflammatory diseases such as inflammatory bowel disease/Crohn's Disease and Blau syndrome.^[2][3]
It is located on chromosome 16 in humans.

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References

1. Innate immune sensing of microbes by Nod proteins, Kufer T, Banks D, Philpott D, , , Ann. N. Y. Acad. Sci., 2006
2. Associations between NOD2/CARD15 genotype and phenotype in Crohn's disease--Are we there yet?, Radford-Smith G, Pandeya N, , , World J. Gastroenterol., 2006
3. Altered host:pathogen interactions conferred by the Blau syndrome mutation of NOD2, Kim T, Payne U, Zhang X, Iwanaga Y, Davey M, Rosenbaum J, Inman R, , , Rheumatol. Int., 2007

External links

http://www.genecards.org/cgi-bin/carddisp.pl?gene=CARD15&search=nod2