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'Anna Angelina' was a daughter of the Byzantine Emperor Alexios III Angelos and of Euphrosyne Doukaina Kamatera.
Her first marriage was to the ''sebastokratōr'' Isaac Komnenos, a great-nephew of the emperor Manuel I Komnenos. They had one daughter, Theodora Angelina. Soon after Anna's father became emperor, in 1195, Isaac Komnenos was dispatched to combat the -Bulgarian Rebellion]]. He was captured, became a pawn between rival Bulgarian and Vlach factions, and died in chains.
Her second marriage to Theodore Laskaris, eventually emperor of Nicaea, was celebrated in a double wedding in early 1200 (the other couple was Anna's sister Eirene and Alexios Palaiologos). Anna and Theodore had three daughters and two sons:
# Erene Laskarina, who married (1) general Andronikos Palaiologos; (2) John III Doukas Vatatzes, emperor of Nicaea
# Maria Laskarina, who married King Bela IV of Hungary
# Eudokia Laskarina
# Nicholas (Nikolaos) Laskaris
# John (Iōannēs) Laskaris

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Sources

Sources

★ K. Varzos, ''I genealogia ton Komninon'' (Thessalonica, 1984).

★ ''O city of Byzantium: annals of Niketas Choniates'' tr. Harry J. Magoulias (Detroit: Wayne State University Press, 1984) especially pages 255–258, 280.