'Alamethicin' is a
peptide antibiotic, produced by the fungus ''
Trichoderma viride''. It contains the non-
proteinogenic amino acid 2-aminoisobutyric acid (Aib), which strongly induces
helical peptide structures. The peptide sequence is:
Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl
(Ac = acetyl, Phl =
phenylalaninol)
★ Molecular Formula: C
92H
150N
22O
25
★
CAS number: 27061-78-5
★ Appearance: Off white solid
★ UV spectrum maxima: 265, 257
★ Melting point: 255°C-270°C
★ Solubility information: DMSO, Methanol, Ethanol. Not soluble in water
In
cell membranes, it forms
voltage-dependent
ion channels by aggregation of four to six
molecules.
data copied from Fermentek Alamethicin product page