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'African swine fever virus' (ASFV) is the causative agent of African swine fever. ASFV infects domestic pigs, warthogs and bushpigs, as well as soft ticks. The virus causes a lethal haemorraghic disease in domestic pigs, some isolates can cause death of animals within as little as a week after infection. In all of the other species the virus causes no obvious disease. ASFV is endemic to Sub-Saharan Africa and exists in the wild through a cycle of infection between ticks and wild pigs/bushpigs/warthogs. ASFV was first described after European settlers brought pigs into areas endemic with ASFV and as such is an example of an 'emerging infection'.

The clinical symptoms of ASFV are very similar to classical swine fever virus and the two diseases normally have to be distinguished by laboratory diagnosis.
African swine fever was restricted to the continent that bears its name until 1957 when the disease was reported in Lisbon, Portugal. A further outbreak occurred here in 1960. Subsequent to these initial introductions the disease became established in the Iberian peninsula and sporadic outbreaks occurred in France, Belgium and other European countries during the 1980's. Both Spain and Portugal had managed to eradicate the disease by the mid 1990's through a slaughter policy. During the late 1970s ASFV crossed the Atlantic Ocean and outbreaks were reported in some Caribbean islands, including Cuba and the Dominican Republic. Major outbreaks of ASFV in Africa are regularly reported to the l'office international des épizooties (OIE). The most recent outbreak of ASFV outside of Africa was in Georgia (country) in April 2007.

The virus itself is a large DNA virus with a genome containing at least 150 genes. The number of genes differs slightly between different isolates of the virus. ASFV has similarities to the other large DNA viruses e.g., poxvirus, iridovirus, mimivirus.
The appearance of ASF in the Western hemisphere at the same time as the emergence of AIDS led to some interest in whether the two were related and a report appeared in the Lancet supporting this in 1986. However, AIDS is now known to be caused by human immunodeficiency virus (HIV), no link between ASFV and AIDS has been proven or is suspected.

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External links

External links

★ OIE Animal Disease Data: http://www.oie.int/eng/maladies/fiches/a_A120.htm

★ Institute for Animal Health Factfile: http://www.iah.bbsrc.ac.uk/schools/factfiles/ASF.htm

★ Department of Environment, Food and Rural Affairs Disease Factsheet: http://www.defra.gov.uk/animalh/diseases/notifiable/asf/index.htm